Epitalon Telomerase Activation Research
Epitalon telomerase research — Khavinson tetrapeptide bioregulator, telomere elongation, pineal gland melatonin restoration, aging research, and lifespan extension studies with citations.
Featured Research
In-depth research profiles with mechanisms of action, key findings, and peer-reviewed citations.
Epithalon (Epitalon)
Also known as: Epithalon, Epithalone, Ala-Glu-Asp-Gly
Epitalon is a synthetic tetrapeptide based on the naturally occurring peptide epithalamin, which is extracted from the pineal gland. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, epitalon is the most extensively studied of the Khavinson peptide bioregulators. Its primary mechanism of action involves activation of telomerase, the enzyme ...
Quick Facts
Sequence: Ala-Glu-Asp-Gly
MW: 390.35 g/mol
CAS: 307297-39-8
Store lyophilized powder at -20C. Reconstituted solution should be refrigerated at 2-8C. As a small tetrapeptide, epital...
Latest Research Articles
Deep-dive articles from the System Peptides Research Network.
Epitalon: Telomerase Activation and Longevity Research
Research review of Epitalon (Epithalon) — the synthetic tetrapeptide studied for telomerase activation, pineal gland fun...
Read Article Category RoundupEssential Peptides for Anti-Aging and Longevity Research
The most studied peptides in aging research — Epitalon, NAD+, MOTS-c, GHK-Cu, and SS-31. Mechanisms, evidence levels, an...
Read Article Research ScienceThe SIRT1-NAD+ Axis: A Key Target in Peptide Longevity Research
How the SIRT1-NAD+ signaling axis connects cellular energy, aging, and peptide interventions like NAD+ supplementation a...
Read ArticleResearch Applications
Key research categories and applications studied in the scientific literature.
Anti-Aging & Longevity
Known for potentially lengthening telomeres — the protective caps on chromosomes — which slows down cellular aging and supports longevity in multiple rodent lifespan studies.
Sleep Optimization
A synthetic peptide that regulates the pineal gland to increase natural melatonin production, promoting a healthier sleep-wake cycle and better sleep quality as organisms age.
Pineal Function
Restores the circadian melatonin rhythm in aged models by stimulating pineal gland function — melatonin being a potent antioxidant and circadian regulator with broad implications.
Frequently Asked Questions
Common questions about epitalon research research, purity standards, and sourcing.
What is Epitalon?
Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide developed by Professor Vladimir Khavinson. It is the synthetic analog of Epithalamin, a pineal gland extract, and is one of the only compounds demonstrated to activate telomerase in human somatic cells.
How does Epitalon activate telomerase?
Epitalon induces telomerase reverse transcriptase (hTERT) expression in human cells, enabling telomere elongation. In Khavinson's studies, Epitalon-treated fibroblasts exceeded the Hayflick limit — undergoing more cell divisions than untreated controls while maintaining telomere length.
What is the connection between Epitalon and melatonin?
Epitalon restores the circadian melatonin rhythm in aged animal models by stimulating pineal gland function. Since melatonin is a potent antioxidant and circadian regulator, this pineal-restorative effect is considered a key mechanism in Epitalon's observed anti-aging properties.
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